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. 2006 Dec 5;103(50):19075–19080. doi: 10.1073/pnas.0607012103

Fig. 5.

Fig. 5.

Correction of hemophilia by implantation of pig E42 spleen tissue. (A) PTT values of wild-type NOD-SCID control mice (n = 10), factor VIII-KO SCID control mice (n = 10), and factor VIII-KO SCID mice (n = 37) transplanted with E42 pig spleen at different time intervals after transplantation. Data contain seven independent experiments. (B) Chromogenic determination of factor VIII activity in plasma of transplanted mice (n = 21). Comparison of factor VIII-KO SCID control mice (gray), wild-type NOD-SCID control mice (black), and factor VIII-KO SCID mice transplanted with E42 pig spleen at different time intervals after transplantation. (C) Survival after tail clipping of NOD-SCID control (black) and factor VIII-KO SCID (white) mice with and without E42 spleen transplantation. The data represent averages of three independent experiments (n > 5 in each experiment).