Table 2.
Genes down-regulated upon antibiotic exposure
| Gene number | Gene product | Fold change |
||
|---|---|---|---|---|
| Tobramycin | Ciprofloxacin | Tetracycline | ||
| PA0527 | Transcriptional regulator Dnr | −7.7 | −3.18 | −3 |
| PA4067 | PAOuter membrane protein OprG precursor | −5.74 | −3.12 | −2.11 |
| PA1561 | Aerotaxis receptor Aer | −4.2 | −2.95 | −2 |
| PA0403 | Regulator PyrR | −3.02 | −2.3 | −2.2 |
| PA5128 | Secretion protein SecB | −2.22 | −2.41 | 1 |
| PA4407 | PAcell division protein FtsZ | −5.57 | −3.25 | −1.66 |
| PA0949 | Trp repressor binding protein WrbA | −3.02 | −2.14 | 1.5 |
| PA1077 | Flagellar basal-body rod protein FlgB | −3 | −2.45 | 1.19 |
| PA0928 | Sensor/response regulator hybrid | −3.9 | −1.97 | −1.26 |
| PA0958 | Basic amino acid and imipenem porin OprD precursor | −3.86 | −2.08 | 1.41 |
| PA5563 | Chromosome partitioning protein Soj | −2.28 | −2.21 | −1.01 |
| PA4366 | PAsuperoxide dismutase | −2.07 | −2.14 | 1.17 |
| PA0594 | Peptidyl-prolyl cis-trans isomerase SurA | −2.65 | −2.03 | −1.32 |
| PA0519 | Nitrite reductase precursor | −3.08 | −1.97 | −3.05 |
| PA0970 | TolR protein | −2.23 | −1.69 | −2.42 |
| PA0972 | TolB protein | −2.24 | −1.94 | −3.39 |
| PA1318 | Probable chemotaxis transducer82–1431058 cytochrome o ubiquinol oxidase subunit I | −2.19 | −1.57 | −5.09 |
| PA0516 | Heme d1 biosynthesis protein NirF | −4.82 | −1.22 | −5.47 |
| PA1094 | Flagellar capping protein FliD | −3.08 | −1.82 | −1.53 |
| PA1094 | Flagellar capping protein FliD | −3.08 | −1.82 | −1.53 |
| PA0024 | Coproporphyrinogen III oxidase, aerobic | −2.95 | −1.43 | −1.68 |
| PA0003 | RecF protein | −2.82 | −1.44 | −1.59 |
| PA4236 | PAcatalase | −2.77 | −1.46 | −1.4 |
| PA3999 | PAD-ala-d-ala-carboxypeptidase | −2.72 | −1.53 | −1.09 |
| PA1081 | Flagellar basal-body rod protein FlgF | −2.71 | −1.28 | −1.24 |
| PA0782 | Proline dehydrogenase PutA | −2.66 | −1.36 | 2.1 |
| PA1092 | Flagellin type B | −3.04 | −1.45 | −1.24 |
| PA0004 | Transcription antitermination protein NusG-6695 DNA gyrase subunit B | −2.49 | −1.45 | −1.16 |
| PA4587 | Cytochrome c551 peroxidase precursor | −2.46 | −1.3 | −1.79 |
| PA4235 | PAbacterioferritin | −2.02 | −1.74 | −1.33 |
| PA4937 | Exoribonuclease RNase R | −2 | −1.16 | −1.38 |
| PA0969 | TolQ protein | −1.97 | −1.25 | −1.56 |
| PA1431 | Regulatory protein RsaL | −1.29 | −2.9 | 1.9 |
| PA0763 | Anti-sigma factor MucA | 1.79 | −2.53 | −1.06 |
| PA4386 | PAGroES protein | −1.06 | −2.3 | −1.15 |
| PA2853 | Outer membrane lipoprotein OprI precursor | −1.58 | −2.26 | 1.08 |
| PA1912 | Probable sigma-70 factor, ECF subfamily | −1.57 | −2.2 | 1.43 |
| PA5040 | Type 4 fimbrial biogenesis outer membrane protein PilQ precursor | −1.41 | −2.15 | 1.11 |
| PA0831 | Transcriptional regulator OruR | 1.19 | −2.05 | −1.31 |
| PA3397 | Ferredoxin–NADP+ reductase | −1.66 | −2 | −1.31 |
| PA3529 | Probable peroxidase | −1.48 | −2 | −1.1 |
| PA3529 | Probable peroxidase | −1.48 | −2 | −1.1 |
| PA4403 | PAsecretion protein SecA | −1.25 | −2 | −1.68 |
| PA0764 | Negative regulator for alginate biosynthesis MucB | 1.2 | 1.23 | −3 |
| PA4761 | DnaK protein | −1.02 | −1.45 | −2.44 |
| PA5053 | Heat shock protein HslV | 1.11 | −1.16 | −2.34 |
| PA1351 | Probable sigma-70 factor, ECF subfamily | 1.32 | 2.48 | −2.31 |
| PA0523 | Cytochrome c subunit of nitric oxide reductase | 2.61 | 1.14 | −2.18 |
| PA5242 | Polyphosphate kinase | −1.75 | −1.23 | −2.14 |
| PA0294 | Transcriptional regulator AguR | −1.1 | −1.58 | −2 |
| PA0857 | Morphogene protein BolA | −1.54 | −1.1 | −2 |
| PA0374 | Cell division protein FtsE | 1.1 | 1.79 | −2 |
| PA0518 | Cytochrome c-551 precursor | −1.93 | −1.88 | −2.89 |
Bold indicates genes with fold change >2 or <−2 and with P < 0.05, and italic indicates genes with fold change >1.5 or <−1.5 and the P < 0.05.