Table 1.

Reactions with significant Z-scores (P<0.10, z>1.28) in response to genetic perturbations by altered redox metabolism and environmental perturbation by oxygen availability^a,b,c

Genetic perturbation (aerobic)			Genetic perturbation (anaerobic)			Environmental perturbation (wild-type strain)
VALsyn	(4/4)	2.90	AGX1	(4/4)	2.67	UGAES	(5/5)	2.41
ALT	(4/4)	2.83	ALT	(4/4)	2.35	ALT	(4/4)	2.34
LEUsynES	(5/6)	2.66	PROsc	(2/3)	2.08	AGX1	(4/4)	2.34
TYRsyn	(3/4)	2.54	LEUsynES	(5/6)	1.80	CAR2	(3/4)	1.95
CAR2	(3/4)	2.50	ASP3-1	(2/3)	1.78	LEUsynES	(5/6)	1.95
PHEsynES	(3/5)	2.25	U46_	(3/4)	1.64	TYRsyn	(3/4)	1.92
AGX1	(4/4)	2.01	CHA1p	(2/3)	1.58	VALsyn	(4/4)	1.87
AAT	(4/4)	1.86	PHEsynES	(3/5)	1.57	PHEsynES	(3/5)	1.74
ILEsynES	(6/7)	1.77	PUT1	(2/3)	1.55	SERsynES	(4/6)	1.67
SUCsc	(2/3)	1.66	VALsyn	(4/4)	1.54	GAD1	(2/3)	1.47
SDH	(2/3)	1.63	GLY1	(2/3)	1.50	GDH13	(3/4))	1.44
HISsynES	(4/10)	1.58	SERsynES	(4/6)	1.41	ASP3-1	(2/3)	1.39
ASP3-1	(2/3)	1.57				GDH2	(3/4)	1.38
GDH2	(3/4)	1.55				MYRsc	(2/2)	1.36
DLD	(2/4)	1.51				ILEsynES	(6/7)	1.36
UGAES	(5/5)	1.48				HISsynES	(4/10)	1.34
SERsynES	(4/6)	1.46				GLYsyn	(2/4)	1.30
LEU4	(2/4)	1.36				U155_	(4/4)	1.29
FUM	(2/2)	1.28

The number of measured metabolites and the total number of metabolites for each reaction are also given in parentheses. The explicit form of the reactions can be followed from Supplementary Table 1.

^aReactions specific to each perturbation are given in bold letters.

^bES means that the corresponding reaction is an enzyme subset consisting of a combination of more than one reaction.

^csc in some of the reaction names stands for ‘secretion', indicating that they are secretion reactions.