Table 2.
Effect of media change (standard medium versus VHG medium) on each strain analyzed by the developed approach; reactions with significant Z-scores (P<0.10, z>1.28) are showna
| Media change for laboratory strain (CEN.PK113-7D) | Media change for industrial strain (Red Star) | ||||||
|---|---|---|---|---|---|---|---|
| zRE | zGE | zRE | zGE | ||||
| ALT | (4/4) | 2.50 | 2.48 | ALT | (4/4) | 2.48 | 1.80 |
| AGX1 | (4/4) | 2.45 | 0.86 | AGX1 | (4/4) | 2.31 | 2.21 |
| UGAES | (5/5) | 2.18 | 1.69 | UGAES | (5/5) | 2.23 | 0.38 |
| ECM40 | (3/4) | 1.85 | 2.39 | U155_ | (4/4) | 2.01 | — |
| GLUsc | (2/3) | 1.85 | 1.17 | ASN | (4/7) | 1.85 | 0.54 |
| ASN | (4/7) | 1.84 | 2.30 | TYRsyn | (3/4) | 1.84 | 3.41 |
| CAR2 | (3/4) | 1.74 | 0.57 | GLUsc | (2/3) | 1.81 | 0.79 |
| LYSsynES | (7/8) | 1.67 | 2.46 | PHEsynES | (3/5) | 1.65 | 0.98 |
| TRP23 | (3/5) | 1.67 | 1.31 | TRP23 | (3/5) | 1.65 | 0.78 |
| ASP3-1 | (2/3) | 1.47 | 1.45 | PROsc | (2/3) | 1.45 | 0.90 |
| CHA1p | (2/3) | 1.47 | 0.93 | ALAsc | (2/3) | 1.45 | 0.75 |
| U42_-43_ | (2/3) | 1.47 | — | GLYsc | (2/3) | 1.45 | 0.80 |
| ASPsc | (2/3) | 1.43 | 2.09 | LACsc | (2/3) | 1.45 | 0.86 |
| PROsc | (2/3) | 1.43 | 1.40 | PYRsc | (2/3) | 1.45 | 0.86 |
| ALAsc | (2/3) | 1.43 | 1.90 | SUCsc | (2/3) | 1.45 | — |
| GLYsc | (2/3) | 1.43 | 1.66 | CITsc | (2/3) | 1.45 | — |
| LACsc | (2/3) | 1.43 | 0.81 | AKGsc | (2/3) | 1.45 | — |
| PYRsc | (2/3) | 1.43 | 0.81 | U88_ | (2/3) | 1.43 | — |
| SUCsc | (2/3) | 1.43 | — | GAD1 | (2/3) | 1.43 | 1.21 |
| GLY1 | (2/3) | 1.41 | 0.41 | ILEsynES | (6/7) | 1.42 | 1.90 |
| VALsc | (2/3) | 1.38 | 1.55 | ASP3-1 | (2/3) | 1.41 | 1.34 |
| PHEsynES | (3/5) | 1.36 | 1.66 | U42_-43_ | (2/3) | 1.41 | — |
| GAD1 | (2/3) | 1.29 | 1.46 | LEUsynES | (5/6) | 1.38 | 0.91 |
| ASPsc | (2/3) | 1.29 | 0.86 | ||||
| ARG5,6-8ES | (4/8) | 1.28 | 0.88 | ||||
Z-scores of the gene expression changes are also given for comparison. zRE: Z-scores of reactions calculated by the developed approach, zGE: Z-scores of genes/gene groups calculated from associated P-values from transcriptome data. The number of measured metabolites and the total number of metabolites for each reaction are also given in parentheses.
aReactions specific to each perturbation are given in bold letters.