Table 3.
List of significant biological processes generated with GOFFA Terms in kidney of rats treated with aristolochic acid (p < 0.01).
| Go term | GO ID | P value (Average) | None of Genes Involved |
| Response to external stimulus | GO:0009605 | 0.000000 | 55 |
| Amino acid and derivative metabolism | GO:0006519 | 0.000000 | 32 |
| Organic acid metabolism | GO:0006082 | 0.000000 | 45 |
| Defense response | GO:0006952 | 0.000000 | 57 |
| Response to biotic stimulus | GO:0009607 | 0.000000 | 59 |
| Carboxylic acid metabolism | GO:0019752 | 0.000000 | 45 |
| Response to wounding | GO:0009611 | 0.000000 | 40 |
| Immune response | GO:0006955 | 0.000001 | 50 |
| Amino acid metabolism | GO:0006520 | 0.000001 | 25 |
| Amine metabolism | GO:0009308 | 0.000001 | 32 |
| Nitrogen compound metabolism | GO:0006807 | 0.000002 | 33 |
| Response to external biotic stimulus | GO:0043207 | 0.000009 | 36 |
| Response to stress | GO:0006950 | 0.00002 | 64 |
| Response to pest, pathogen or parasite | GO:0009613 | 0.000024 | 34 |
| Amino acid biosynthesis | GO:0008652 | 0.000028 | 9 |
| Induction of programmed cell death | GO:0012502 | 0.000084 | 19 |
| Induction of apoptosis | GO:0006917 | 0.000084 | 19 |
| Positive regulation of biological process | GO:0048518 | 0.000162 | 48 |
| Positive regulation of programmed cell death | GO:0043068 | 0.000245 | 19 |
| Positive regulation of apoptosis | GO:0043065 | 0.000245 | 19 |
| Amine biosynthesis | GO:0009309 | 0.000247 | 11 |
| Nitrogen compound biosynthesis | GO:0044271 | 0.000247 | 11 |
| Sulfur amino acid metabolism | GO:0000096 | 0.000430 | 6 |
| Generation of precursor metabolites and energy | GO:0006091 | 0.000444 | 39 |
| Complement activation, classical pathway | GO:0006958 | 0.000645 | 6 |
| Positive regulation of cellular process | GO:0048522 | 0.000699 | 39 |
| Positive regulation of physiological process | GO:0043119 | 0.000849 | 37 |
| Humoral defense mechanism (sensu Vertebrata) | GO:0016064 | 0.000874 | 10 |
| Positive regulation of cellular physiological process | GO:0051242 | 0.000902 | 35 |
| Regulation of programmed cell death | GO:0043067 | 0.001275 | 27 |
| Regulation of lymphocyte proliferation | GO:0050670 | 0.001318 | 6 |
| Regulation of immune response | GO:0050776 | 0.001579 | 11 |
| Amine catabolism | GO:0009310 | 0.001671 | 9 |
| Regulation of lymphocyte activation | GO:0051249 | 0.001739 | 8 |
| Regulation of apoptosis | GO:0042981 | 0.002010 | 26 |
| Amino acid catabolism | GO:0009063 | 0.002152 | 8 |
| Regulation of cell activation | GO:0050865 | 0.002152 | 8 |
| Nitrogen compound catabolism | GO:0044270 | 0.002422 | 9 |
| Sulfur metabolism | GO:0006790 | 0.002637 | 8 |
| Aspartate family amino acid metabolism | GO:0009066 | 0.002692 | 4 |
| Negative regulation of biological process | GO:0048519 | 0.002726 | 45 |
| Electron transport | GO:0006118 | 0.002754 | 23 |
| Cellular catabolism | GO:0044248 | 0.002821 | 27 |
| Xenobiotic metabolism | GO:0006805 | 0.003190 | 6 |