Table 4.
List of significant biological processes generated with GOFFA Terms in liver of rats treated with aristolochic acid (p < 0.01).
| Go term | GO ID | P value (Average) | Number of Genes Involved |
| Steroid metabolism | GO:0008202 | 0.000000 | 16 |
| Sterol metabolism | GO:0016125 | 0.000000 | 12 |
| Steroid biosynthesis | GO:0006694 | 0.000000 | 13 |
| Cholesterol biosynthesis | GO:0006695 | 0.000000 | 9 |
| Sterol biosynthesis | GO:0016126 | 0.000000 | 11 |
| Cellular lipid metabolism | GO:0044255 | 0.000002 | 27 |
| Lipid metabolism | GO:0006629 | 0.000003 | 30 |
| Terpenoid metabolism | GO:0006721 | 0.000009 | 4 |
| Polyisoprenoid metabolism | GO:0016096 | 0.000009 | 4 |
| Terpene metabolism | GO:0042214 | 0.000009 | 4 |
| Lipid biosynthesis | GO:0008610 | 0.000012 | 15 |
| Cholesterol metabolism | GO:0008203 | 0.000021 | 9 |
| Isoprenoid metabolism | GO:0006720 | 0.000021 | 6 |
| Isoprenoid biosynthesis | GO:0008299 | 0.000059 | 4 |
| Alkene metabolism | GO:0043449 | 0.000147 | 5 |
| Alcohol metabolism | GO:0006066 | 0.000203 | 16 |
| Xenobiotic metabolism | GO:0006805 | 0.000830 | 5 |
| Secondary metabolism | GO:0019748 | 0.000830 | 5 |
| Response to toxin | GO:0009636 | 0.001363 | 4 |
| Polyisoprenoid biosynthesis | GO:0009241 | 0.001364 | 2 |
| Pyrimidine deoxyribonucleotide metabolism | GO:0009219 | 0.001364 | 2 |
| Terpene biosynthesis | GO:0046246 | 0.001364 | 2 |
| Terpenoid biosynthesis | GO:0016114 | 0.001364 | 2 |
| Organic cation transport | GO:0015695 | 0.001567 | 3 |
| Response to xenobiotic stimulus | GO:0009410 | 0.001584 | 5 |
| Alkene biosynthesis | GO:0043450 | 0.002440 | 3 |
| Regulation of transferase activity | GO:0051338 | 0.002531 | 8 |
| Regulation of protein kinase activity | GO:0045859 | 0.002531 | 8 |
| Regulation of cyclin dependent protein kinase activity | GO:0000079 | 0.002970 | 4 |
| Cell growth | GO:0016049 | 0.003636 | 9 |
| Regulation of cell size | GO:0008361 | 0.003939 | 9 |
| Positive regulation of neuron differentiation | GO:0045666 | 0.003992 | 2 |
| Retinal metabolism | GO:0042574 | 0.003992 | 2 |
| Apocarotenoid metabolism | GO:0043288 | 0.003992 | 2 |
| Regulation of cell growth | GO:0001558 | 0.004043 | 8 |
| Regulation of growth | GO:0040008 | 0.004604 | 9 |
| Growth | GO:0040007 | 0.005932 | 11 |
| Hormone-mediated signaling | GO:0009755 | 0.007789 | 2 |
| Deoxyribonucleotide metabolism | GO:0009262 | 0.007789 | 2 |
| Response to hormone stimulus | GO:0009725 | 0.007789 | 2 |
| G2/M transition of mitotic cell cycle | GO:0000086 | 0.007897 | 4 |
| Electron transport | GO:0006118 | 0.009494 | 13 |