Figure 3.
Endogenous secretion of MDC from uninfected MDM and HIV replication. MDM culture supernatants from different donors were collected at day 5 and tested for their contents of MDC before infection with HIV-1BaL (A). In some experiments, infections by ADA (B) and by two primary HIV isolates (DUR, R5, and GRA, R5/X4) also were performed. A strong inverse association between levels of endogenously secreted MDC (low: <15 ng/ml, full symbols; high: >15 ng/ml, open symbols) and HIV replicative ability in these MDM cultures was observed.