Table 3.
Frequency of pathological lesions in SOCS-1 −/− IFNγ +/− and control mice
| Parameter | Percentage of mice with various lesions
|
|||
|---|---|---|---|---|
| SOCS-1 −/−IFNγ +/−(n = 38) | SOCS-1 +/−IFNγ +/−(n = 11) | SOCS-1 −/−IFNγ −/−(n = 22) | SOCS-1 +/+ IFNγ −/−(n = 22) | |
| Muscle infiltration | ||||
| Massive | 79 | 0 | 0 | 0 |
| Minor | 18 | 0 | 0 | 0 |
| Heart infiltration | ||||
| Massive | 47 | 0 | 0 | 0 |
| Minor | 36 | 0 | 0 | 0 |
| Corneal infiltration | 68 | 0 | 0 | 0 |
| Ulcer | 39 | 0 | 0 | 0 |
| Marrow excess eosinophils | 68 | 10 | 50 | 0 |
| Lymphoid foci | ||||
| Lung | 97 | 0 | 64 | 0 |
| Salivary gland | 81 | 0 | 0 | 0 |
| Liver | 21 | 0 | 0 | 0 |
| Kidney | 24 | 0 | 0 | 0 |
| Excess plasma cells | 43 | 0 | 37 | 0 |
| Thymus cortex atrophy | 88 | 0 | 5 | 0 |
| Skin, patches of epithelial thickening | 43 | 9 | 0 | 0 |
| Liver, excess hematopoietic cells | 68 | 8 | 18 | 18 |