Figure 3.
Effects of a single i.v. injection of cytotoxic somatostatin conjugate AN-238 on primary pancreatic cancer growth in hamsters. PC-1.0 (open bars), PC-1.0/sst2 (hatched bars), and a mixture of PC-1.0/sst2 and PC-1.0 cells (ratio of PC-1.0/sst2 to PC-1.0 = 25:75; filled bars) were inoculated orthotopically into the tail of the pancreas of hamster (5 × 105 per site). Tumor volumes were measured at day 13 as described for Exp. 2 and at day 20 in group that did (+) or did not (−) receive single i.v. injections of 100 nmol/kg of AN-238 at day 13 according to Exp. 3. Values are from 20 animals at day 13 from four separate experiments and from 10 animals per group at day 20 from two separate experiments. Difference from control tumors (open bar): *, P < 0.001; †, P < 0.01. Difference between sst2 and mixed tumor volume at 13 days: ‡, P < 0.05. Difference with tumor volume at 20 days in untreated animals: §, P < 0.01; ¶, P < 0.05.