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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1984 Nov;36(6):1341–1348.

Familial premature ovarian failure.

D R Mattison, M I Evans, W B Schwimmer, B J White, B Jensen, J D Schulman
PMCID: PMC1684657  PMID: 6517055

Abstract

Premature menopause, ovarian failure younger than 40 years of age, is relatively rare but may preclude childbearing for some women who delay attempts at fertility. We present five kindreds in which a genetic association for premature ovarian failure is strongly suggested. Transmission is either autosomal or (less likely) X-linked dominant in these examples. Chromosomal abnormalities, history of diseases, and toxic chemical or viral exposures previously associated with premature ovarian failure could not be demonstrated in these women. This suggests that these kindreds all represent familial idiopathic premature ovarian failure. These data support the need for menopausal histories on both sides of the family for women seeking to postpone reproduction, as well as for patients with ovarian failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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