Figure 2.

(A) Clinical phenotype of an H+ T+ female mouse at 5 months of age (Lower) showing significantly smaller size and lower back muscle wasting compared with a female H+ littermate (Upper). (B) Locomotor activity in pairs of mice at 3.5 months after the induction of the transgene. Total distance P < 0.001; vertical activity P < 0.0001. (C) Serum creatine phosphokinase (CK), P < 0.01; and glutamic-oxaloacetic transaminase (GOT) levels P < 0.01 (n = 8 per group); H+ T+ (filled bars) and control H+ or T+ female littermates (empty bars).