Figure 6.

The readministration of doxycycline to H+ T+ mice manifesting disease. (A) Hematoxylin-eosin staining of skeletal muscle; (1) T+ mouse at 9 months of age; (2) H+ T+ mouse without doxycycline at 9 months of age; and (3) H+ T+ mouse retreated with doxycycline for 5 months after 4 months without doxycycline. (B) Locomotor activity (total distance and vertical activity); lane 1, T+ mice (white bar); lanes 2 and 3, H+ T+ mice without doxycycline (black bar); and H+ T+ mice retreated with doxycycline for 5 months after 4 months of disease (red bar). (C) Northern blot analysis of skeletal muscle mRNA for endogenous H-2K^b and ICAM-1. Control T+ (lane 1) and H+ T+ mice before and after readministration of doxycycline (lanes 2 and 3).