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Inactivation of wild-type p53 transcriptional activity in RKO and HCT 116 cells treated with electrophilic PG. PGA1 (▵) and PGA2 (▿) inhibited the basal transactivation of a p53-Luc reporter in RKO cells (Upper) and HCT 116 cells (Lower). PGA1 (▴) and PGA2 (▾) also inhibited etoposide (Etop)-induced transactivation of a p53-Luc reporter in RKO cells (Upper) and HCT 116 cells (Lower) with a potency ≅ 20 μM.
