Figure 7.

Effect of i.v. injections into immunocompetent mice of the adenoviral vector encoding the mfVIIasm immunoconjugate on the growth of a mouse skin melanoma. C57BL/6 mice were injected s.c. with the mouse melanoma line B16F10, and when a skin tumor had grown to the size indicated on day 0 the mice were injected intravenously with 3 × 10¹⁰ IP of the vector encoding the mfVIIasm immunoconjugate. The Fc domain of the immunoconjugate was derived from a mouse IgG1 immunoglobulin. The mice were injected intravenously again on day 5 with 1.5 × 10¹⁰ IP of the same vector.