Table 1.

Inhibition of metastatic lung tumors by intratumoral injections of adenoviral vectors encoding the immunoconjugates

Adenoviral vectors	Number of tumors on the surface of the lungs
Control	14, 29
Encoding the immunoconjugates	1, 5, 0, 0, 0

SCID mice were injected on day 0 with human melanoma cells intravenously to generate bloodborne metastatic lung tumors and subcutaneously to generate a skin tumor, as described in the text. Intratumoral injections of the adenoviral vectors encoding the mfVIIasm and G71-1 immunoconjugates into the skin tumor were started on day 12, and additional injections were done biweekly for 8 weeks. The autopsies were done 2 days after the last injection. The number of mice was 2 for the control vector and 5 for the vectors encoding the immunoconjugates.