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Repeated imaging of gene expression in the same mouse. The PRG is a point-mutated HSV1-tk optimized for ganciclovir and penciclovir. PRG is FPCV. The combination of the point mutation and FPCV provides a signal-to-noise improvement of 6 over HSV1-tk and FGCV. The Swiss/Webster mouse is a wild type, and the nude mouse has immature immune system. % ID is percent injected dose of FPCV per gram of tissue.
