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. 2000 Jul 25;97(16):9252–9257. doi: 10.1073/pnas.160171697

Figure 3.

Figure 3

Sequence comparison of the N-terminal 90 (88 HLA-DP β*02012) residues of the mature HLA class II β-chains is shown. Connected arrows indicate the positions of the double amino acid substitutions. Open arrow indicates that a E→V substitution in HLA-DQ β*0201 at position 46 disrupts entry-mediating activity. Solid arrows indicate that substitutions at these positions did not alter entry-mediating activity. Shaded residues, 45 and 46, demonstrate the conservation of glutamic acid among beta alleles that mediate EBV entry. HLA-DR amino acid residues involved in peptide binding are marked with *; barred region indicates the residues involved in the homodimerization of HLA-DR molecules.