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. 2000 Jul 25;97(16):9252–9257. doi: 10.1073/pnas.160171697

Figure 4.

Figure 4

Glutamic acid at residue 46 is necessary for EBV coreceptor activity. Shown is the susceptibility of 721.174 cells transfected with the indicated HLA-DQ β cDNAs to infection by EBfaV-GFP as analyzed by two-color flow cytometry. Mutant HLA-DQ β*0201 alleles were cotransfected with HLA-DQ α*0501; HLA-DQ β*03032 alleles were cotransfected with HLA-DQ α*0301. Numbers in the upper right-hand quadrants represent the percentage of HLA-DQ-expressing cells infected by EBfaV-GFP. The value for pSG5-transfected cells is >0.00%. CLIP expression was determined and found to be proportional to HLA-DQ levels at the time of infection (data not shown). Dot plots contain 40,000 events.