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. 1977 Sep;29(5):523–536.

Recombination, mutation, or constitutive expression at a Gm locus and familial hypergammaglobulinemia.

G Lefranc, L Rivat, J P Salier, E van Loghem, H Aydenian, P Zalzal, L Chakhachiro, J Loiselet, C Ropartz
PMCID: PMC1685403  PMID: 900125

Abstract

In a hypercholesterolemic Lebanese family, an uncommon Gm haplotype carrying an unexpected C gamma 1 gene was inherited by only one of 10 siblings. A new recombination during the maternal or paternal meiosis could explain its formation. According to this hypothesis, our data would be informative for the linkage relationship between the gamma-cistrons and the alpha 2-cistron. The latter might be located near the N-terminal side of the gamma-cistron linkage group, and the sequence of genes would be alpha 2, gamma 4, gamma 3, and gamma 1. A mutation could also effect the change from G1m(17) (codons AAA and AAG) TO G1m(3) (codons AGA and AGG). Another alternative is to postulate a constitutive expression of a C gamma 1 structural gene which, normally, would not be expressed. The uncommon derepression could be the consequence of uncommon cellular response to environmental, pathological or metabolic perturbation of a regulatory mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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