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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1983 Sep;35(5):1042–1047.

A new rare variant of the glyoxalase I system of the red cell: GLO-Sicily.

M Beretta, G Schilirò, A Russo, G Barbujani, P Mazzetti, G Russo, I Barrai
PMCID: PMC1685809  PMID: 6613997

Abstract

A fast variant of the red cell enzyme glyoxalase I was identified in a sample of 663 persons from Eastern Sicily; the allele was designated GLOSi. The gene frequencies for the common alleles GLO1 and GLO2 are not different from those observed in other southern Italian populations, and are in agreement with the hypothesis of a westward gene flow from Asia.

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Selected References

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  1. Berg K., Rodewald A., Schwarzfischer F., Wischerath H. Population genetics of glyoxalase I (E.C.4.4.1.5) in human erythrocytes. Z Rechtsmed. 1977 Jan 21;79(1):13–15. doi: 10.1007/BF00204539. [DOI] [PubMed] [Google Scholar]
  2. Golan R., Ben-Ezzer J., Szeinberg A. Erythrocyte glyoxalase I polymorphism in several population groups in Israel. Hum Hered. 1979;29(1):57–60. doi: 10.1159/000153016. [DOI] [PubMed] [Google Scholar]
  3. Kavathas P., DeMars R. A new variant glyoxalase I allele that is readily detectable in stimulated lymphocytes and lymphoblastoid cell lines but not in circulating lymphocytes or erythrocytes. Am J Hum Genet. 1981 Nov;33(6):935–945. [PMC free article] [PubMed] [Google Scholar]
  4. Kömpf J., Bissbort S., Gussmann S., Ritter H. Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic marker in man. Investigation of 169 mother-child combinations. Humangenetik. 1975;27(2):141–143. doi: 10.1007/BF00273329. [DOI] [PubMed] [Google Scholar]
  5. Kühnl P., Schwabenland R., Spielmann W. Investigations on the polymorphism of glyoxalase I (EC 4.4.1.5) in the population of Hessen, Germany. Hum Genet. 1977 Aug 31;38(1):99–106. doi: 10.1007/BF00295812. [DOI] [PubMed] [Google Scholar]
  6. Mauff G., Wachauf P., Schaal K. P., Pulverer G. GLO I and Bf phenotype distribution in a West German population sample. Hum Hered. 1978;28(6):431–434. doi: 10.1159/000152995. [DOI] [PubMed] [Google Scholar]
  7. Meera Khan P., Doppert B. A. Rapid detection of glyoxalase I (GLO) on cellulose acetate gel and the distribution of GLO variants in a Dutch population. Hum Genet. 1976 Sep 10;34(1):53–56. doi: 10.1007/BF00284434. [DOI] [PubMed] [Google Scholar]
  8. Menozzi P., Piazza A., Cavalli-Sforza L. Synthetic maps of human gene frequencies in Europeans. Science. 1978 Sep 1;201(4358):786–792. doi: 10.1126/science.356262. [DOI] [PubMed] [Google Scholar]
  9. Olaisen B., Teisberg P., Jonassen R. GLO polymorphism in Norway. Hum Hered. 1976;26(6):454–457. doi: 10.1159/000152840. [DOI] [PubMed] [Google Scholar]
  10. Parr C. W., Bagster I. A., Welch S. G. Human red cell glyoxalase I polymorphism. Biochem Genet. 1977 Feb;15(1-2):109–113. doi: 10.1007/BF00484553. [DOI] [PubMed] [Google Scholar]
  11. Pausch V., Fachleutner G., Kirnbauer M., Mayr W. R. Polymorphism of glyoxalase I in Vienna. Hum Hered. 1979;29(4):204–207. doi: 10.1159/000153044. [DOI] [PubMed] [Google Scholar]
  12. Pflugshaupt R., Scherz R., Bütler R. Human red glyoxalase I polymorphism in the Swiss population: phenotype frequencies and a simplified technique. Hum Hered. 1978;28(3):235–237. doi: 10.1159/000152962. [DOI] [PubMed] [Google Scholar]
  13. Ranzani G., Antonini G., Santachiara-Benerecetti A. S. Red cell glyoxalase I polymorphism in Italians. Report of a variant phenotype. Hum Hered. 1979;29(5):261–264. doi: 10.1159/000153055. [DOI] [PubMed] [Google Scholar]
  14. Rittner C., Weber W. Evidence for a 'silent allele' GLO0 at the glyoxalase I locus. Hum Genet. 1978 Jun 27;42(3):315–318. doi: 10.1007/BF00291312. [DOI] [PubMed] [Google Scholar]
  15. Rubinstein P., Suciu-Foca N. Glyoxalase 1: a possible 'null' allele. Hum Hered. 1979;29(4):217–220. doi: 10.1159/000153047. [DOI] [PubMed] [Google Scholar]
  16. Uotila L. Glutathione thiol esterases of human red blood cells. Fractionation by gel electrophoresis and isoelectric focusing. Biochim Biophys Acta. 1979 Oct 24;580(2):277–288. doi: 10.1016/0005-2795(79)90140-5. [DOI] [PubMed] [Google Scholar]
  17. Uotila L. Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver. Biochemistry. 1973 Sep 25;12(20):3944–3951. doi: 10.1021/bi00744a025. [DOI] [PubMed] [Google Scholar]
  18. VALENTINE W. N., TANAKA K. R. The glyoxalase content of human erythrocytes and leukocytes. Acta Haematol. 1961;26:303–316. doi: 10.1159/000206665. [DOI] [PubMed] [Google Scholar]
  19. Vergnes H., Meyer S., Weil D., Goudemand J., Brevière D., Sevin J., Constans J. Erythrocyte glyoxalase I and esterase D polymorphisms in four French populations. Hum Hered. 1980;30(4):232–236. doi: 10.1159/000153134. [DOI] [PubMed] [Google Scholar]

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