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. 2000 Aug 1;97(16):9299–9304. doi: 10.1073/pnas.97.16.9299

Figure 1.

Figure 1

Expression of PS1 and PS2 in WT and asp-mutant PS1/PS2 cells. (a) CHO cells stably expressing WT PS1, D385A PS1, or D257A PS1 plus D366A PS2 were lysed and immunoprecipitated (IP) with PS1 polyclonal antibodies X81 to the NTF, R22 to both NTF and CTF, or preimmune serum (pre) from rabbit X81. The precipitates were probed by Western blotting (WB) with PS1 mAb 13A11 to the CTF. (b) Lysates from untransfected cells or PS1/PS2 double asp-mutant cells were immunoprecipitated and Western blotted with PS2 antibody 2972.