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. 2000 Jul 25;97(16):9305–9310. doi: 10.1073/pnas.160128797

Figure 5.

Figure 5

Effects of anesthetics on α1 or α1(S267C) GlyR, expressed in Xenopus oocytes, before and after perfusion with PMTS. (A) In α1 receptors, enflurane (1.2 mM), isoflurane (0.6 mM), or octanol (0.1 mM) enhanced glycine responses before and after application of PMTS (30 μM). (B) In mutant α1(S267C) receptors, application of PMTS abolished the effects of enflurane, isoflurane, or octanol. PMTS was perfused for 60 s before being coapplied with glycine for 30 s. Anesthetics or octanol were tested again after 15 min of washout from PMTS. Data are expressed as a mean ± SEM of three to four oocytes.