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Overlay of three crystallographically determined structures. The structure in green was determined after soaking N-tosyl-d-proline (free acid) into crystals of unmodified TS. The structure in red is TS covalently modified by N-tosyl-d-proline disulfide-bonded to C146 (the active-site cysteine). Finally, the structure in blue is mutant TS (C146S/L143C) covalently modified by N-tosyl-d-proline disulfide bonded to L143C.
