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Comparative Src SH2 binding affinities (IC50s) for compounds 1, 3, AP22408, AP22409, and AP22650 using a competitive fluorescence polarization assay
| Compound | Src (IC50 μM) |
|---|---|
| 1 | 5.56 ± 0.21 |
| 3 | 2.2 ± 0.09 |
| AP22408 | 0.30 ± 0.06 |
| AP22650 | 1.3 ± 0.16 |
| AP22409 | >500 |
