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. 2006 Nov 28;4:7. doi: 10.1186/1476-8518-4-7

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Copyright © 2006 Huang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of the magnitude and breadth of HIV-specific responses between TI#1, TI#2, and TI#3. A. The magnitude of responses to peptide panels increased significantly by a mean of 457 SFC/10⁶PBMC from TI#1 to the TI#2 (p = 0.016), and 20 SFC/10⁶PBMC from the TI#2 to TI#3 (n.s.). B. The magnitude of responses to Gag p55 peptide pools increased by a mean of 754 SFC/10⁶PBMC from the TI#1 to TI#2 (p = 0.039), and decreased by a mean of 302 SFC/10⁶PBMC from the TI#2 to TI#3 (n.s) C. The breadth of responses to the HIV peptide panels used for screening increased significantly by a mean of 2.00 peptides from the TI#1 to TI#2 (p = 0.031) and decreased by a mean of 0.56 peptides from the TI#2 to TI#3 (n.s.) D. Comparison of the magnitude of the change in IFN-γ responses from the first to the second time point tested in continuously treated HIV-infected subjects (controls) and between TI#1 and TI#2 in the study population. The bar in each scatter plot shows the mean change in SFC/10⁶PBMC. The magnitude of the change differed significantly between the controls and the study population (-240 ± 331 versus +457 ± 475 SFC/10⁶PBMC respectively, p = 0.0028; Mann-Whitney test); n.s.= not significant.