Table 4.

Association between genotypes of MMP and colorectal adenomas

	Large adenoma patients (LA)	Polyp free controls (PF)	Small adenoma patients (SA)	LA vs PF		LA vs SA		SA vs PF
				OR* (95%CI)	P**	OR* (95%CI)	P**	OR* (95%CI)	P**
MMP1
1G/1G	81	154	81	1		1		1
1G/2G	139	285	139	0.94 (0.66–1.33)		1.04 (0.69–1.56)		0.96 (0.67–1.37)
2G/2G	72	122	79	1.18 (0.78–1.78)	0.491	0.90 (0.56–1.43)	0.792	1.22 (0.81–1.84)	0.431
MMP3.1
5A/5A	70	130	68	1		1		1
5A/6A	139	291	132	0.87 (0.60–1.25)		1.10 (0.72–1.69)		0.85 (0.58–1.24)
6A/6A	73	126	93	1.11 (0.73–1.69)	0.391	0.78 (0.48–1.25)	0.250	1.50 (0.99–2.28)	0.008
MMP3.2
AA	182	358	194	1		1		1
AG	105	187	92	1.10 (0.81–1.50)		1.20 (0.83–1.73)		0.87 (0.64–1.20)
GG	7	19	16	0.72 (0.29–1.78)	0.615	0.49 (0.19–1.27)	0.175	1.34 (0.65–2.75)	0.464
MMP7
AA	92	187	99	1		1		1
AG	138	259	136	1.08 (0.77–1.50)		1.06 (0.72–1.56)		0.98 (0.70–1.38)
GG	64	119	67	1.17 (0.78–1.77)	0.742	1.08 (0.67–1.72)	0.944	1.14 (0.76–1.71)	0.746

* OR adjusted on age, sex, and group of centres

** P: p-value for the Wald test assessing the global effect of SNP, uncorrected for multiple testing