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Two distinct chemical reactions efficiently catalyzed by GST A1–1 and GST A4–4. The reaction mechanisms differ; GST A1–1 favors an aromatic substitution reaction by which the sulfur of glutathione (γ-Glu-Cys-Gly) replaces the chlorine atom of CDNB. GST A4–4 has the highest activity in the Michael addition reaction where glutathione is added to the activated double bond of an alkenal. One subunit of each enzyme is shown (A1 and A4).
