Figure 1.

Induction of AVD (A) and facilitation of RVD (B) by the 2-h treatment with STS or TNF/CHX, and their prevention by simultaneous treatment with a channel blocker, 0.5 mM NPPB, 30 μM phloretin, 0.5 mM DIDS, 5 mM Ba²⁺, or 0.5 mM quinine in U937, HeLa, NG108-15, and PC12 cells. Cell volume measurements were performed in the absence of any drugs after washing out apoptotic inducers and channel blockers, and the data were normalized by those measured immediately before the 2-h treatment (A) or a hypotonic challenge (B). Each data represents the mean ± SEM (vertical bar) of 16 observations. *, P < 0.05 vs. corresponding control.