Figure 5.

Absence of Hox11 and Bapx1 expression in splenic primordium of capsulin^−/− mice. Bapx1 and Hox11 transcripts were detected by in situ hybridization to abdominal sections of wild-type and capsulin mutant embryos at E12.5–14.5, as indicated. Both transcripts were detected in the region of the splenic anlage at E12.5 but were not detected thereafter. The sections on the left are representative sections of adjacent wild-type or mutant embryos stained with hematoxylin/eosin. a, adrenal gland; dm, dorsal mesogastrum; g, gut; k, kidney; l, liver; p, pancreas; sp, spleen; st, stomach.