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. 2000 Aug 1;97(17):9561–9566. doi: 10.1073/pnas.160105897

Figure 2.

Figure 2

From the first clinical signs of arthritis, mice were given CBD by oral gavage, at the following doses: 50 mg/kg (▵), 25 mg/kg (▴), or 10 mg/kg (○). Mice treated with olive oil served as controls (□). Each point is the mean of n mice ± SEM. (A) Shown is the clinical score over 10 days of classical CIA (controls, n = 6; CBD 50 mg/kg, n = 6; CBD 25 mg/kg, n = 6; CBD 10 mg/kg, n = 6). * denotes a P value < 0.05 (Mann–Whitney U test). (B) An experiment in chronic relapsing homologous CIA, where control, n = 6 and CBD 25 mg/kg, n = 6. The area under the curve was 72.3 for the control group and 49.7 for the CBD-treated group (P < 0.05, Mann–Whitney U).