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AG-1478 inhibits DNA synthesis in mammary epithelium from MMTV/Neu + TGF-α bigenic mice. (a and b) Mice were injected daily for 5 days with DMSO (a) or AG-1478 (b). On the fifth day, BrdUrd was injected i.p. 2 h before isolation of one of the inguinal mammary glands. Tissue sections were prepared and subjected to immunohistochemistry with a BrdUrd antibody as described in Materials and Methods. (Magnification: ×400.)
