Table 3.
Modification status of chromosomal DNA from 16 H. pylori strains
| Modification site |
H. pylori strains examined†
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A101 | J166 | 60190 | 9366 | 26695 | 97690 | CH4 | HPK5 | J99 | J178 | J188 | J195 | J262 | 8822 | 97762 | 98518 | |
| GANTC | + | − | +* | − | + | − | − | − | + | + | + | − | + | − | + | + |
| CCGG | + | + | +* | + | − | + | + | + | + | + | + | + | + | + | + | + |
| GAAGA | − | − | +* | − | + | + | − | + | − | +* | − | + | − | + | − | − |
| TCNNGA | + | − | + | − | − | + | +* | − | − | +* | +* | + | + | + | + | + |
| GGATG | − | − | − | − | − | − | − | − | − | +* | − | − | − | − | − | − |
| GGCC | − | − | − | − | − | + | − | − | − | +* | − | − | − | − | − | − |
| TCNGA | − | +* | − | − | − | − | − | − | − | − | +* | − | − | − | − | − |
| GTSAC | + | − | − | + | + | + | + | + | +* | − | + | + | + | + | + | + |
| GCGC | + | + | + | + | + | + | + | + | +* | + | + | + | + | + | + | + |
| CATG | + | + | + | + | + | + | +* | + | + | + | + | + | + | + | + | + |
| CTNAG | − | − | − | + | − | + | +* | + | − | − | − | − | + | + | − | − |
| ACNGT | + | − | − | − | − | + | +* | − | − | + | − | + | − | − | + | − |
| ACGT | + | − | + | − | − | − | +* | + | + | − | − | + | + | + | + | + |
| TGCA | − | + | − | + | − | − | +* | + | − | − | − | − | − | + | + | + |
| CCTC | + | +* | + | + | + | + | − | + | + | − | + | + | + | + | + | + |
“+” indicates “modified,” and “−” indicates “not modified.”
*
Restriction enzymes isolated from each of the six strains (J166, 60190, CH4, J99, J178, and J188) correspond to the methylation in their DNA.
†
Strains from A101 to HPK5 have the iceA1 genotype; strains from J99 to 98518 have the iceA2 genotype.