Figure 6.

Caveolin-3 (Cav-3) transgenic mice have elevated levels of serum creatine kinase (CK), consistent with myo-necrosis. Creatine kinase activity was measured in serum from normal control mice and caveolin-3 transgenic mice by using a standard colorimetric assay. Note that caveolin-3 transgenic mice exhibit elevated serum creatine kinase activity (≈4- to 5-fold), as compared with normal control mice. Values represent the average of eight measurements (performed in duplicate) from four different control mice and four different caveolin-3 transgenic mice.