Figure 1.

Suppression of inclusion formation by apGroEL, MC₇, Hsp104 wt, and Hsp104 K620T in COS-7 (a and b) and PC12 (c and d) cells. In all experiments, the odds ratios are derived from 2–4 independent experiments, each done in triplicate, where we have compared test constructs with pFLAG. (Error bars = 95% confidence intervals for the odds ratios.) (a) COS-7 cells cotransfected with EGFP-HDQ74 and apGroEL and control plasmids. (b) COS-7 cells cotransfected with EGFP-HDQ53 and all test and control plasmids. (c) PC12 cells cotransfected with EGFP-HD74 and apGroEL and control plasmids. (d) PC12 cells cotransfected with EGFP-HD74 and all test and control plasmids (except for apGroEL, which is shown in c). *, P < 0.05; **, P < 0.001; ***, P < 0.0001; NS = P > 0.05.