Table 1.
Elevation in CBF produced by hypercapnia in APP mice or in C57BL/6J mice with Aβ superfusion
| Mice | Normocapnia
|
Hypercapnia
|
CBF, % increase | n |
|---|---|---|---|---|
| pCO2, mmHg | pCO2, mmHg* | |||
| APP, Tg lines | ||||
| 6209− | 34.0 ± 0.5 | 55.2 ± 1.6 | 68.6 ± 5.2 | 6 |
| 6209+ | 35.3 ± 0.4 | 57.9 ± 0.8 | 69.0 ± 5.6 | 6 |
| 2123F− | 33.0 ± 0.8 | 53.4 ± 0.6 | 68.2 ± 5.1 | 6 |
| 2123F+ | 33.4 ± 0.5 | 55.0 ± 0.5 | 67.3 ± 5.0 | 6 |
| 2123F−/PS1mut+ | 34.2 ± 1.4 | 55.3 ± 0.7 | 69.5 ± 4.1 | 6 |
| 2123F+/PS1mut+ | 35.5 ± 0.8 | 55.2 ± 1.0 | 66.4 ± 3.0 | 6 |
| 2123M− | 35.0 ± 0.2 | 54.0 ± 1.3 | 71.4 ± 4.4 | 6 |
| 2123M+ | 33.2 ± 0.4 | 53.3 ± 1.7 | 68.2 ± 6.8 | 6 |
| C57BL/6J with Aβ superfusion | ||||
| Aβ1-40 | 6 | |||
| Ringer | 34.7 ± 0.4 | 54.5 ± 0.8 | 66.8 ± 1.6 | |
| 5 μM Aβ | 35.7 ± 0.7 | 55.4 ± 0.8 | 77.5 ± 3.2 | |
| Aβ1-42 | 6 | |||
| Ringer | 34.5 ± 0.7 | 54.9 ± 1.2 | 64.4 ± 2.3 | |
| 5 μM Aβ | 35.7 ± 1.0 | 54.9 ± 0.9 | 73.2 ± 2.1 | |
| Aβ40-1 | 6 | |||
| Ringer | 33.1 ± 0.4 | 54.8 ± 0.7 | 63.4 ± 3.6 | |
| 5 μM Aβ | 35.7 ± 0.7 | 55.7 ± 0.6 | 75.0 ± 4.0 |
Mean ± SE, *, P < 0.05 from normocapnia (t test); no differences in mean arterial pressure and pO2, were found between normocapnia and hypercapnia (P < 0.05, ANOVA).