Table 1.

Description of the representative structures analyzed in surface comparison: PKA (c-AMP-dependent protein kinase), Cdk2 (cyclin-dependent kinase 2), Lck (human lymphocyte kinase), Src (human tyrosine-protein kinase), and Irk (human insulin receptor)

Name	PDB ID	Chain	Functional state	Other components	Phosphorylated residues	Ref.
PKA	2CPK	E	Active	Peptide inhibitor	S-139, T-197, S-338	25
Cdk2	1FIN	A	Active	Bound to cyclin, ATP	—	11
Cdk2	1HCL	—	Inactive	—	—	26
Lck	3LCK	—	Active	SO4	Y-394	27
Src	2SRC	—	Inactive	AMP-PNP	Y-527	28
Irk	1IR3	A	Active	AMP-PNP, Mg	Y-1158, Y-1162, Y-1163	29
Irk	1IRK	—	Inactive	—	—	30

The PDB ID numbers of the structures, functional configuration, bound ligands and phosphorylated residues are shown. AMP-PNP, 5′-adenyly-imido-triphosphate; PDB, Protein Data Bank.