Fig. 1.

Extended genomic organization of POTE genes. (A) Genomic organization of POTE paralogs are depicted. Domain organization and exon numbers are given at the top. Primer binding sites (arrows) and query sequences for the database search (probe 1 and probe 2) are marked at the bottom. Plain boxes indicate exons derived from the ancestral gene ANKRD26. The actin inserts and LINE elements are represented by stippled and hatched boxes, respectively. The ORFs are color-coded: orange, cysteine-rich domains (CRDs); blue, ankyrin repeats (ANKs); green, helices; and red, actin. (B) Actin insert and surrounding sequences are presented. The putative target site duplication (TSD) is marked. Dashes and dots indicate gaps and omitted bases, respectively.