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. 2000 Aug 1;97(17):9765–9770. doi: 10.1073/pnas.170160397

Figure 1.

Figure 1

Effects of immunophilin ligands on arterial BP and renal efferent SNA in WT mice. (a) Effects of CsA in a WT mouse. Pulsatile BP and segments of multifiber action potentials of renal efferent SNA were recorded before and after CsA (10 mg/kg i.v.). In this WT mouse, BP and renal efferent SNA increased after CsA. (b) Effects of three immunophilin ligands in WT mice. Changes in MAP and renal efferent SNA were recorded during and after i.v. infusion of CsA (10 mg/kg, n = 7), FK506 (0.3 mg/kg, n = 11), rapamycin (0.3 mg/kg, n = 5), or vehicle (n = 5). MAP and renal efferent SNA increased similarly with CsA or FK506, but were unaffected by rapamycin or vehicle, suggesting calcineurin mediation. (c) Effects of VGX in WT mice. Changes in renal efferent SNA and MAP were recorded during and after CsA in intact WT mice and those with bilateral cervical VGX. CsA-induced increases in renal efferent SNA and MAP were almost abrogated by VGX (n = 7), indicating vagal afferent mediation of these reflex responses. Horizontal bars denote the period of CsA, FK506, rapamycin, or vehicle infusion. *, P < 0.05, compared with baseline (time 0).