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Transformation of the parent strain with mutated PBP 2B and/or 2X transpeptidase domains from the resistant mutant PR1_2evolved
| Recipient | Donor | Mutations | MIC increase | Mutation in transformanta |
|---|---|---|---|---|
| Wild type | 2B | T450A/V596F | 2× | — |
| Wild type | 2X | G545S/Q548E | 8× | Q548E |
| Wild type | 2B | T450A/V596F | 8-16× | V596F |
| 2X | G545S/Q548E | 8-16× | Q548E |
—, no detected mutation.
