. 2006 Oct 16;50(12):4191–4194. doi: 10.1128/AAC.01110-06

TABLE 2.

Quinolone susceptibilities and resistance mechanisms in 10 isolates displaying levofloxacin MICs of ≥4 μg/ml

Strain no., species	MIC (μg/ml) against the following quinolone:					Mutation(s) in QRDR^a		Efflux mechanism (no. of doubling dilutions)^b
Strain no., species	DX-619	Levofloxacin	Moxifloxacin	Sitafloxacin	Gatifloxacin	GyrA	ParC	Efflux mechanism (no. of doubling dilutions)^b
68, S. salivarius	0.03	4	0.5	0.25	1	NC	S79R, M116I	+ (2)
116, S. bovis	0.06	>32	4	0.5	8	H43D, G79C	S79F, D83N	−
118, S. bovis	0.016	4	0.5	0.12	0.5	NC	M116I	+ (1)
121, S. bovis	0.12	4	2	0.25	2	S81L	NC	−
122, S. bovis	0.12	8	2	0.25	2	S81L	NC	−
124, S. bovis	0.12	>32	8	1	16	S81F	Y15D, S79F	−
125, S. bovis	0.03	4	0.5	0.12	1	NC	Y15D	−
132, S. bovis	0.25	>32	16	2	>32	S81L	S79Y	−
193, S. oralis	0.06	16	4	0.5	8	NC	S79Y	+ (1)
216, S. oralis	0.03	8	2	0.25	2	S81F, Y107I	D83N	+ (1)

NC, no change compared to susceptible strain or susceptible S. pneumoniae R6. Used is S. pneumoniae R6 numbering (sequence NCBI accession numbers AAK99902 [GyrA] and AAK99561 [ParC]).

−, efflux mechanism absent; +, efflux mechanism present.