TABLE 2.

Association of K65R with other RT mutations in viruses from patients infected with HIV-1 subtype C and treated with ddI/d4T

Patient no.	NRTI mutation(s)	Time of first appearance of K65R (after commencement of ddI/d4T-based therapy) (mo)	Polymorphisms
3	K65R, S68G, F116Y, Q151M, M184V	18	V35T, E36A, T39E, S48T, T69I, D123S, S163C, K166Q, K173T, Q174R, T200A, I202V, E203K, Q207A, H208Y, R211E, L214F, V245M, D250E, R277K, E291D, V292I, I293V, D324E
6	K65R, S68G, K70R, V75I, F116Y, Q151M	4	V35Q, T39D, S48T, V60I, T69I, I135T, E138A, I142T, Q151L, K173A, Q174K, D177E, I178V/L, G196E, T200A, Q207E, R211K, V245K, D250E, R277K, E291D, V292I, I293V, V317A, Q334N
7	K65R	4	V35T, T39K, S48E, T69N, E122K, D123E, I135M, K173T/I, T200A, Q207E, R211K, L214F, V245Q, P272A, R277K, K281R, T286A, E291D, V292I, I293V, E312F, V314P
10	K65R	4	T39E, E40K, D67G, T69N, E122K, K173A, G177G/R, T200A, Q207E, R211K, L214F, H221H, L228L/R, V245E, D250E, E291D, V292I, I293V, I326V, Q334H
13	K65R, S68G, K70R, F77L, Y115F, F116Y, Q151M, K219E	6	V35T, E36A, T39E, T58N, V75A, D123S, R172K, K173T, D177E, I178M, T200A, Q207K, R211K, L214F, P225H, V245Q, E248D, E291D, V292I, I326V, Q334D
15	K65R	12	V35T, T39E, S48T, D123G, K173E, D177G, T200A, Q207K, R211K, L214F, V245Q, E248D, P272S, T286A, L289I, E291D, V292I, Q334N
16	K65R, M184V	11	T27S, V35T, T39E, S48T, D123G, T139K, S162C, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K, L214F, L228R, V245Q, P272S, E291D, V292I, I293V, Q334N