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. 2006 Oct 23;50(12):4206–4208. doi: 10.1128/AAC.00793-06

TABLE 1.

In vitro inhibition of T. gondii by artemisinin and synthetic derivatives

Compounda Mol wt ID50
TD50
TI
μg/ml μM μg/ml μM
Artemisinin 282.34 2.3 8.0 >320b >1,130 ≥243
Artemether 298.4 0.2 0.7 220 740 1,100
    2d 464.68 0.5 1.1 160 340 320
    2c 509.43 0.6 1.2 >320b >630 ≥933
    2b 430.54 0.6 1.4 >320b >740 ≥933
    2a 326.43 2.7 8.3 510 1,560 190
    Deoxy-2a 310.43 173 560 200 640 1.2
Trimethoprim 290.3 5.2 17.9 60 210 12
a

The parent compound is shown first followed by the known derivative. The five new derivatives are listed in decreasing order of efficacy according to concentrations in μg/ml.

b

Toxicity endpoint was not reached; a value 1/4 log greater than the concentration tested was used to compute the TI.