FIG. 2.

Effect of treatments on triglyceridemia and glycemia. (A) Mice were treated daily for 2 weeks with increasing doses of the LPV/r (100/25, 200/50, or 300/75 mg/kg/day or control treatment), as indicated. Blood samples were analyzed for their triglyceride (TG) concentrations. The histogram shows the mean values for four animals per condition. (B) Mice were treated daily for 2 to 8 weeks, as indicated, with LPV/r at 200/50 mg/kg/day or with excipient alone (controls [Con]) and were analyzed for their triglyceride concentrations. The values are the means for 4 to 10 animals per group. (C) Mice were treated daily for 2 weeks with the LPV/r at 200/50 mg/kg/day or the excipient alone (controls), and glycemia was measured. The histogram shows the mean values for four animals per condition. (D) Mice were treated daily for 8 weeks with the LPV/r at 200/50 mg/kg/day, ATV at 90 mg/kg/day, or excipient alone (controls); and the triglyceride concentrations were measured. The histogram shows the mean values for 23 control animals, 17 LPV/r-treated animals, and 12 ATV-treated animals. Values are given as the means ± standard errors of the means. N.S., nonsignificant.