TABLE 2.
Estimated FICI values for combinations of antimicrobial agents
| Antimicrobial agent A
|
Antimicrobial agent B
|
FICI | Ratingb | ||
|---|---|---|---|---|---|
| Compound | Classa | Compound | Classa | ||
| Nitrite | S | Bronopol | T | 0.28 | Synergistic |
| Glutaraldehyde | X | Bronopol | T | 0.28 | Synergistic |
| Nitrite | S | Glutaraldehyde | X | 0.30 | Synergistic |
| Nitrite | S | Benzalkonium chloride | C | 0.30 | Synergistic |
| Benzalkonium chloride | C | Bronopol | T | 0.33 | Synergistic |
| Glutaraldehyde | X | Benzalkonium chloride | C | 0.35 | Synergistic |
| Glutaraldehyde | X | Molybdate | S | 0.37 | Synergistic |
| Cocodiamine | C | Bronopol | T | 0.39 | Synergistic |
| Glutaraldehyde | X | Formaldehyde | X | 0.48 | Synergistic |
| Molybdate | S | Formaldehyde | X | 0.50 | Synergistic |
| Nitrite | S | Cocodiamine | C | 0.53 | Synergistic |
| Benzalkonium chloride | C | Formaldehyde | X | 0.57 | Synergistic |
| Nitrite | S | Molybdate | S | 0.59 | Synergistic |
| Benzalkonium chloride | C | Cocodiamine | C | 0.63 | Synergistic |
| Nitrite | S | Formaldehyde | X | 0.67 | Synergistic |
| Benzalkonium chloride | C | Molybdate | S | 0.69 | Synergistic |
| Bronopol | T | Formaldehyde | X | 0.80 | Synergistic/indifferent |
| Molybdate | S | Bronopol | T | 0.80 | Synergistic/indifferent |
| Cocodiamine | C | Molybdate | S | 0.83 | Indifferent |
| Glutaraldehyde | X | THPS | U | 0.90 | Indifferent |
| Cocodiamine | C | Formaldehyde | X | 1.00 | Indifferent |
| Nitrite | S | THPS | U | 1.05 | Indifferent |
| Benzalkonium chloride | C | THPS | U | 1.05 | Indifferent |
| Glutaraldehyde | X | Cocodiamine | C | 1.06 | Indifferent |
| THPS | U | Molybdate | S | 1.17 | Indifferent |
| THPS | U | Formaldehyde | X | 1.57 | Antagonistic |
| Cocodiamine | C | THPS | U | 1.50 | Antagonistic |
| THPS | U | Bronopol | T | 2.00 | Antagonistic |
a
S, metabolic inhibitor of sulfate reduction; X, cross-linking agent; C, cationic surfactant; T, thiol inactivator; U, unknown.
b
Mixtures were considered synergistic when the lowest FICI was <0.8, indifferent when 0.8 < FICI < 1.2, and antagonistic when the highest FICI was >1.2.