. Author manuscript; available in PMC: 2006 Dec 11.

Published in final edited form as: Nat Genet. 2005 Sep 4;37(10):1047–1054. doi: 10.1038/ng1634

Table 1.

Primary tumor formation and secondary metastasis. Incidence of tumor formation and metastasis in mice subcutaneously injected with melanocyte (Mel-STR), mammary epithelial cell (MEC-STR) and fibroblast (BJ-STR) cells engineered to express the SV40ER, hTERT and RasV12. Also shown are melanocytes expressing the SV40ER, hTERT and a vector control (Mel-STV). S,O indicate subcutaneous and orthotopic injections, respectively. NA, not applicable.

1^o Tumor		Mel-STR	Mel-STV	MEC-STR	BJ-STR
		93/93	0/12	21/21 (S)	21/21
		93/93	0/12	20/20 (O)	21/21
Metastasis				1/21 (S)
	Any organ	85/93	NA	0/21 (O)	0/21
	Lung	85/93	NA	1/21 (S)	0/21
				0/21 (O)
	Liver	25/93	NA	0/21 (S,O)	0/21
	Spleen	21/93	NA	0/21 (S,O)	0/21
	Small bowel	11/93	NA	0/21 (S,O)	0/21
	Lymph nodes	27/93	NA	0/21 (S,O)	0/21