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. 2006 Oct 13;5(12):1969–1979. doi: 10.1128/EC.00230-06

TABLE 1.

Equilibrium association constants for complexes of Leishmania elF4E isoforms and mouse eIF4E (amino acids 28 to 217) with cap analoguesd

Cap analogue Kas (μM−1) for:
Mouse eIF4E (28-217) LeishIF4E-1 LeishIF4E-2 LeishIF4E-3 LeishIF4E-4
m7GTP 121.4 ± 3.0a 0.16 ± 0.02 0.037 ± 0.006 0.32 ± 0.07 0.8 ± 0.08
m7GpppA 4.4 ± 0.1a 0.072 ± 0.002b 0.016 ± 0.010 0.020 ± 0.005 0.21 ± 0.03
Cap 1
    m7Gpppm36,6,2′ A 1.45 ± 0.03a 0.065 ± 0.004b 0.020 ± 0.004 0.029 ± 0.007 0.075 ± 0.031
Cap 2
    m7Gpppm36,6,2′ Apm2′ A 10.7 ± 1.4 0.067 ± 0.005 0.092 ± 0.008 0.063 ± 0.010 0.23 ± 0.06
Cap 3
    m7Gpppm36,6,2′ Apm2′ Apm2′ C 22.2 ± 1.0 0.19 ± 0.01 0.24 ± 0.02 ND ND
Cap 4
    m7Gpppm36,6,2′ Apm2′ Apm2′ Cpm23,2′ U 26.1 ± 0.7a 0.253 ± 0.003b 0.28 ± 0.04 0.046 ± 0.02 0.77 ± 0.08
Cap 0
    m7GpppApApCpU 73.3 ± 1.8a 0.467 ± 0.005c 0.089 ± 0.013 0.12 ± 0.03 2.0 ± 0.4
TMG
    m32,2,7GTP 0.64 ± 0.06 <0.01 <0.003 <0.04 <0.006
GTP 0.032 ± 0.004a <0.01 <0.003 <0.01 <0.01
a

Data from reference 22.

b

Data from reference 6.

c

Data for LeishIF4E-1 (amino acids 12 to 214) (22).

d

Data are presented as means ± standard deviations. ND, not determined.