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Disruption of M. tuberculosis whiB3. (a) Genomic map of whiB3 and flanking genes in M. tuberculosis H37Rv. (b) AES used to make a whiB3 knockout mutant. The shaded box with a hyg cassette represents the region deleted from whiB3. (c) Genomic fragment PCR amplified to create a ΔwhiB3attB::whiB3 complement. (d) Phenotypic confirmation of ΔwhiB3 by real-time RT-PCR. The expression of whiB3 transcript in H37Rv, ΔwhiB3 (whiB3 mutant), and ΔwhiB3attB::whiB3 (whiB3 complement) is shown.
