TABLE 1.

Effect of CD4⁺- or CD4⁺- and CD8⁺-T-cell depletion after reconstitution on the P. carinii burden in P. carinii-infected SCID mice reconstituted with splenocytes from P. carinii-naïve mice

Expt	Day	No. of P. carinii organisms/mouse			P valuea
		No depletion	CD4+-T-cell-depleted mice	CD4+- and CD8+-T-cell-depleted mice
1	10	8.07 × 106 ± 8.56 × 105	1.40 × 107 ± 5.50 × 106
	14	8.57 × 106 ± 9.38 × 105	1.31 × 107 ± 1.75 × 106
	21	1.58 × 107 ± 1.10 × 107	5.33 × 107 ± 7.95 × 106
2	7	8.06 × 105 ± 1.53 × 105	7.55 × 105 ± 1.96 × 105	5.76 × 105 ± 1.38 × 105	NS
	10	2.10 × 106 ± 2.83 × 105	1.33 × 106 ± 2.87 × 105	6.96 × 105 ± 1.13 × 105	NS
	14	2.29 × 106 ± 7.20 × 105	1.69 × 106 ± 7.02 × 105	1.73 × 106 ± 9.48 × 105	NS
3	10	1.6 × 107 ± 1.91 × 106	1.76 × 107 ± 1.62 × 106	2.28 × 107 ± 3.88 × 106	NS

^aP value for a comparison of CD4⁺-T-cell-depleted mice and CD4⁺- and CD8⁺-T-cell-depleted mice. NS, not significant.