TABLE 3.
Impact of CD8+ T cells on control of P. carinii in P. carinii-inoculated mice with CD4+ T cells depleted or CD4+ and CD8+ T cells depleted
Weeks postinfection | No. of P. carinii organisms/mouse
|
|
---|---|---|
CD4+-T-cell-depleted mice | CD4+- and CD8+-T-cell-depleted mice | |
3 | 7.10 × 106 ± 7.71 × 105 (6)a | 4.42 × 106 ± 3.25 × 105 (6) |
4 | 8.41 × 106 ± 7.83 × 105 (6) | 6.27 × 106 ± 8.42 × 105 (6) |
6 | 1.73 × 107 ± 6.95 × 106 (6) | 6.82 × 106 ± 1.16 × 106 (6) |
P = 0.01 for a comparison of CD4+-T-cell-depleted mice and CD4+- and CD8+-T-cell-depleted mice. Numbers in parentheses indicate the number of mice per group.