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. 2006 Sep 5;74(11):6501–6504. doi: 10.1128/IAI.00597-06

FIG. 2.

FIG. 2.

Infection of female 129 mice caused an influx of macrophages, PMNs, and NK cells into the spleen. Leukocyte populations in the spleen were analyzed by flow cytometry for the percentages of macrophages, CD4+ T cells, CD8+ T cells, PMNs, and NK cells in mice infected with Y. pestis KIM5 (open bars) or the YopM− strain (closed bars) on day four postinfection. The data represent the average results ± standard deviations (error bars) from three infected mice; data for noninfected mice are provided for reference (hatched bars). The values for macrophages, PMNs, and NK cells for mice infected with both Y. pestis KIM5 and the YopM− strain differed significantly from those for noninfected mice by the unpaired t test (n = 3), with two-tailed P values of 0.011, 0.0026, and 0.034 for the three mice infected with Y. pestis KIM5 and 0.017, 0.018, and 0.0038 for the three mice infected with the YopM− strain. The same statistical test found no significant difference between the values for Y. pestis KIM5 and the YopM− mutant for macrophages, PMNs, NK cells, or CD8+ T cells. The difference in values for CD4+ T cells in mice infected with the parent and mutant strains was statistically significant but was not always observed.